What is a Monoclonal Antibody?
A Monoclonal antibody is derived from a single antibody producing B cell (plasma cell). Monoclonal antibodies have monovalent affinity which means that they only bind with one unique epitope which is the part of an antigen that is recognized by the antibody. Monoclonal antibodies are artificially produced against a specific antigen in order to bind to their target antigens using hybridoma technology that involves fusing myeloma cells with mouse spleen cells immunized with the desired antigen of interest so that large quantities of identical antibody can be generated. For applications such as therapeutic drug development that requires large volumes of identical antibody specific to a single epitope, monoclonal antibodies can be an ideal solution.
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